Technology

Integrating analytical chemistry, systems biology, and data science to redefine the management of metabolic health

Understanding Metabolic Health

Metabolic health is about how your body processes food, aiming to stabilize blood sugar, fat, inflammation, and insulin levels after meals. Stability prevents issues like high cholesterol and hypertension. Being metabolically healthy reduces the risk of obesity, diabetes, heart disease, and more. Despite age and genetics being fixed, we can improve metabolic health through proper diet, weight management, adequate sleep, regular exercise, and stress management. The Maven Health metabolic test aids these efforts by identifying key focus areas. Essentially, maintaining balance with food and lifestyle habits helps prevent serious future health issues.

Metabolomics; a window into our metabolic health

Metabolomics offers a unique glimpse into our metabolic health, providing insights into how our bodies function on a molecular level. Think of it as a window through which we can observe the chemical processes that occur within our cells.

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In simple terms, metabolomics is the study of the small molecules produced during these processes, known as metabolites. These molecules serve as markers of cellular activity, offering clues about our overall health. By analyzing the patterns and levels of metabolites in cells, tissues, or organisms, we can uncover valuable information about metabolic function and potential health risks.

Essentially, metabolomics allows us to examine the chemical fingerprints left behind by cellular processes, giving us a comprehensive view of our metabolic profile. It's like taking a snapshot of our internal chemistry, helping us understand how our lifestyle choices impact our health.

Clinical Value

While traditional blood biomarkers like cholesterol and HbA1c provide valuable insights into metabolic health, their primary strength lies in diagnosing conditions that are already well-established rather than in the early detection of metabolic dysfunction. These markers give a crucial snapshot of health but may not always indicate emerging issues before they develop into recognizable diseases. In contrast, our metabolomics approach offers a comprehensive view by analyzing a broad spectrum of metabolites simultaneously, not just single markers. This holistic perspective allows for earlier interventions and a proactive optimization of metabolic health.

The Science and Technology behind the test

Saliva contains relevant metabolites like amino acids, short-chain fatty acids, and glucose intermediates for assessing metabolic health. We use Nuclear Magnetic Resonance (NMR) spectroscopy, a precise analytical technique, to measure these metabolites in saliva. Our custom software suite automates data processing, translating NMR spectra into clear metabolite quantities. This technology provides precise metabolic profiles, enabling personalized health assessments efficiently and reliably. Additionally, our algorithms produce personalized health scores based on these profiles, offering actionable insights that empower individuals to optimize their metabolic health.

Our Metabolites Library
Selected Publications
Plasma metabolites to profile pathways in noncommunicable disease multimorbidity
Maik Pietzner, Isobel D. Stewart, Johannes Raffler, Kay-Tee Khaw, Gregory A. Michelotti, Gabi Kastenmüller, Nicholas J. Wareham & Claudia Langenberg
Natural Medicine

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